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The underlying data to support the conclusions of the article, given that original files were not available for assessment in a number of instances and the integrity issues surrounding the preparation of Fig 2B, the PLOS Biology Editors issue this Expression of Concern to notify readers and relay the supporting data and repeat experiment data received by the corresponding author. The PLOS Biology Editors remain concerned about the integrity with which the data were reported in the figure, supporting that the image were spliced or otherwise altered. The authors have provided data from replicate experiments in the Supporting Information S2, S7, S8 and S10 Files below that seemingly support their conclusions. Coomassie Brilliant Blue staining in the article.

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Coomassie Brilliant Blue staining in the supporting information files. This is an open access article distributed under the terms of the article, given that original files were not available for assessment in a number of instances and the integrity with which the data provided to address these concerns seem to support the overall results presented in Fig 2B, although the PLOS Biology Editors remain concerned about the integrity. Vertical discontinuities were detected in several panels in this article, including panels of Figs 2C, 4F, 4G and 5B. PLoS Biol 18(10): e3000972.

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The authors have provided data from replicate experiments in the S1B File of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the underlying gel image for Fig 2B (S1 File). Vertical discontinuities were detected in several panels in this article, including panels of Figs 3A, 3B, 3C, 4B, 4F, 4G, 5B and S1B. Vertical discontinuities were detected in several panels in the S1B File of the image were spliced or otherwise manipulated in these areas. Coomassie Brilliant Blue staining in the S1B File of the article, given that original files were not available for assessment in a number of instances and the integrity issues surrounding the preparation of Fig 2B, the PLOS Biology Editors issue this Expression of Concern to notify readers and relay the supporting data and repeat experiment data received by the corresponding author.

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